Biomechanics and Electrophysiology of Sensory Regulation during Locomotion in a Novel in Vitro Spinal Cord-hindlimb Preparation
نویسندگان
چکیده
منابع مشابه
An in vitro spinal cord-hindlimb preparation for studying behaviorally relevant rat locomotor function.
Although the spinal cord contains the pattern-generating circuitry for producing locomotion, sensory feedback reinforces and refines the spatiotemporal features of motor output to match environmental demands. In vitro preparations, such as the isolated rodent spinal cord, offer many advantages for investigating locomotor circuitry, but they lack the natural afferent feedback provided by ongoing...
متن کاملInnovative Methodology An In Vitro Spinal Cord–Hindlimb Preparation for Studying Behaviorally Relevant Rat Locomotor Function
Hayes HB, Chang Y-H, Hochman S. An in vitro spinal cord– hindlimb preparation for studying behaviorally relevant rat locomotor function. J Neurophysiol 101: 1114–1122, 2009. First published December 10, 2008; doi:10.1152/jn.90523.2008. Although the spinal cord contains the pattern-generating circuitry for producing locomotion, sensory feedback reinforces and refines the spatiotemporal features ...
متن کاملEnabling techniques for in vitro studies on mammalian spinal locomotor mechanisms.
The neonatal rodent spinal cord maintained in vitro is a powerful model system to understand the central properties of spinal circuits generating mammalian locomotion. We describe three enabling approaches that incorporate afferent input and attached hindlimbs. (i) Sacral dorsal column stimulation recruits and strengthens ongoing locomotor-like activity, and implementation of a closed positive-...
متن کاملStance-phase force on the opposite limb dictates swing-phase afferent presynaptic inhibition during locomotion.
Presynaptic inhibition is a powerful mechanism for selectively and dynamically gating sensory inputs entering the spinal cord. We investigated how hindlimb mechanics influence presynaptic inhibition during locomotion using pioneering approaches in an in vitro spinal cord-hindlimb preparation. We recorded lumbar dorsal root potentials to measure primary afferent depolarization-mediated presynapt...
متن کاملNeuro Forum Sensory regulation of quadrupedal locomotion: a top-down or bottom-up control system?
Thibaudier Y, Hurteau MF. Sensory regulation of quadrupedal locomotion: a top-down or bottom-up control system? J Neurophysiol 108: 709 –711, 2012. First published April 18, 2012; doi:10.1152/jn.00302.2012.—Propriospinal pathways are thought to be critical for quadrupedal coordination by coupling cervical and lumbar central pattern generators (CPGs). However, the mechanisms involved in relaying...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010